expert roundtable discussion
ADC Roundtable: Bioanalytical Workflows, Sample Prep, & Instrumentation Insights
Monday, September 28, 2026 | 12:00 PM Eastern
ADCs are one of the fastest-growing therapeutic classes in drug development, with 80+ candidates now in the clinical pipeline. But every ADC creates multiple bioanalytical questions: free payload, conjugated payload, total antibody, and beyond. Each requires its own sample prep strategy, extraction decisions, and sensitivity considerations.
In this roundtable, bioanalytical scientists from KCAS Bio and SCIEX share practical approaches to ADC quantitation by LC-MS/MS, from sample preparation tradeoffs to multiplexing strategies and instrumentation choices that impact your PK data.
Speakers
Rathna Veeramachaneni, Ph.D.
Director, Mass Spec Bioanalysis – Development, KCAS Bio
Ebru Selen
Staff Scientist, Pharma/Biopharma Quant, SCIEX
Ryan Darling
Associate Director, Mass Spec Bioanalysis – Development, KCAS Bio
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What you'll learn
How ADC structure shapes your bioanalytical strategy
When to use IP vs. direct digest workflows
Sample prep tradeoffs that impact your LLOQ
How multiplexing reduces variability utilizing single sample volume
What instrument sensitivity means for real-world ADC PK